Cell type- and density-dependent effect of 1 T static magnetic field on cell proliferation
نویسندگان
چکیده
Increasing evidence shows that static magnetic fields (SMFs) can affect cell proliferation but mixed results have been reported. Here we systematically examined the effects of 1 T (Tesla) SMF, which is close to the SMF intensity that patients are exposed to MRI (magnetic resonance imaging) scanners in hospitals, for its effect on 15 different cell lines, including 12 human and 3 rodent cell lines. Our results show that 1 T SMF does not have apparent impact on cell cycle or cell death. However, at higher cell density, it reduced cell numbers in six out of seven solid human cancer cell lines. We found that both cell type and cell density had evident impacts on SMF effects. Moreover, the EGFR-Akt-mTOR pathway, which varies significantly between different cell types and densities, contributes to the differential effects of SMF. In addition, SMF also increases the efficacy of Akt inhibitors on cancer cell growth inhibition. Therefore 1 T SMF affects cell proliferation in a cell type- and cell density-dependent manner, and the inhibition effect of 1 T SMF on multiple cancer cells at higher cell density may indicate its clinical potential in late stage cancer therapy.
منابع مشابه
Anticancer Effects of Moderate Static Magnetic Field on Cancer Cells in Vitro
Background: Expansion of the use of magnetic fields in metals, mining, transport, research, and medicine industries has led to a discussion about the effects of magnetic fields and whether their strength is negligible. The aim of this study was to investigate the effects of magnetic field on the viability and proliferation rate of HeLa cells. Materials and methods: We studied the effects of ma...
متن کاملThe modeling of induced current density in eyes from static magnetic fields produce by MR scanner
Introduction: Staff and patient Movement in static magnetic field MRI scanner induces current density in the human tissues, so cause biologic effects in people. The aim of this study was the Modelling of current density induced by moving individual with different velocities in static magnetic field of magnetic resonance imaging. Materials and Methods: current ...
متن کاملThe Inhibitory Effects of Static Magnetic Field on Escherichia coli from two Different Sources at Short Exposure Time
This study was intended to investigate the effectiveness of static magnetic field on the growth of Escherichia coli (E. coli) provided from two sources, the urine samples of patients with urinary tract infections and the reference strain E. coli ATCC 25922. Bacterial samples in Nutrient Broth were subjected to a range of magnetic intensities (2, 4, 6, 9, 14, 16, 18, and 20 mT) at various exposu...
متن کاملPentacyclic Triterpenes in Euphorbia microsciadia with Their T-cell Proliferation Activity
The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass ...
متن کاملPentacyclic Triterpenes in Euphorbia microsciadia with Their T-cell Proliferation Activity
The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass ...
متن کامل